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Our Science Initiatives

At the forefront of biomedical innovation, our stem cell research spans three key areas:

Disease Research:
We investigate how diseases develop at the cellular level, using stem cells to model conditions, explore disease mechanisms, and develop new therapies.

Developmental Biology:
By studying how stem cells contribute to human development, we gain critical insights into the processes that guide cell growth and differentiation.

Regenerative Medicine:
Harnessing the power of stem cells, we aim to repair or replace damaged tissues and organs—paving the way for transformative treatments.

fsoncin@ucsd.edu

Francesca Soncin, PhD

Assistant Professor, Pathology

We study the mechanisms that establish a trophoblast stem cell population during early development, which then differentiate to form the mature placenta in both normal and diseased pregnancies.

mfwilkinson@ucsd.edu

Miles Wilkinson, PhD

Professor, Obstetrics, Gynecology, and Reproductive Sciences

Our studies are centered on the impact of gene regulatory circuits in normal development and disease, In particularin how transcriptional and post-transcriptional pathways control normal development and how their disruption causes disease.

kwillert@ucsd.edu

Karl Willert, PhD

Associate Professor, Cellular & Molecular Medicine

As a model system to study to role of Wnt signaling, we primarily use human pluripotent stem cells (including both embryonic and induced pluripotent stem cells).

geneyeo@ucsd.edu

Eugene Yeo, PhD

Professor, Cellular & Molecular Medicine

Our focus is in understanding the importance of RNA processing and the roles that RNA binding proteins (RBPs) play in development and disease. in particular on uncovering molecular principles by which RBPs affect gene expression, how RBP- mediated post-transcriptional gene networks contribute to cellular homeostasis in stem cells and the brain, and how mutations in RBPs lead to human developmental and neurodegenerative disease.

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